People in areas that were heavily bombed are more likely to experience poor nutrition in childhood and have lower education. It is difficult to disentangle exactly why bombing has these long-term effects on disability.Ī likely explanation is that people in heavily bombed areas continue, many years later, to suffer from direct exposure to the bombing and connected weaponry, including unexploded bombs, landmines and military herbicides more commonly known as Agent Orange. Around 40,000 have lost their lives in such accidents. In districts that saw more bombings, Vietnamese people born before around 1990 have higher rates of disability than those in other parts of the country.Īs one New York Times story noted, since the end of the war, more than 67,000 Vietnamese have been maimed by unexploded cluster bombs, losing limbs or eyes. However, perhaps surprisingly, there also seems to be a relationship between the bombings and those born as long as 15 years after the war. In districts with high levels of bombing, disability rates were highest for people around 40 years of age, the group born in the late 1960s during the heaviest level of wartime bombing. In our study, we looked more closely at the total number of bombs, missiles and rockets per square kilometer, and how that related to the proportion of people with disability at different ages. However, war may have other, hidden effects on the health of populations, including among people born after the war. Walking the streets of Ho Chi Minh City, one can see the high number of elderly amputees, whose injuries likely stemmed from the war. Injuries and impairments sustained among people directly exposed to the bombing are not surprising. Michael Palmer, Nora Groce and Sophie Mitra, CC BY-SA Vietnam disability rates in 2009, by district.
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If you’re very brave… or very stupid… you could jump straight in, no tools, no armor, no preparation. Right at spawn, you have access to an End Portal - complete with all its Ender Eyes. Our last seed brings us not only to the end of our list, but to the end of the game. It’s unclear what the Pillagers are planning, but I’m certain it’s nothing good. If you’re lucky, your adventure may last long enough for you to come across the ruined portal the house has been hiding. 2103285228 - Impossible Jungle Templeįor our final woodland mansion seed, I take you inside the walls of the dreaded manse to risk death on the off-chance you might uncover the deeds of the Pillagers residing among its rooms. You’ll have to be a fast-thinker, quick on your feet, to make it out with your brains intact - especially with no tools or weapons to protect yourself with! 5. It spawns you right inside an abandoned village - infested with zombie villagers that are hungry for flesh. If you’re interested in living your own mini Walking Dead series, this seed is for you. …except Netherite, that’s a pretty good thing, I guess. Repair it at your own risk - I promise that nothing good awaits you on the other side. In this seed, you spawn near a village with a ruined Nether portal located at its center. Screams heard from empty tunnels, candles flickering in caves where no breeze can be found… in Minecraft, however, those rumors are never just rumors. Here in the real world, there are many locations that are rumored to be haunted or cursed or referred to as gateways to the Underworld. So why has no one asked how many organisms must die to feed mushrooms the size of trees? What are those cows eating to produce fungi all over their backs? And what could truly be buried in that massive cavern, located in the middle of the biome? Only exploration is sufficient to reveal. See, mushrooms are, by nature, decomposers. But something that few ever talk about is… where mushrooms come from. After all, mooshrooms are the cutest mob in the game. Now, hear me out - a seed that spawns you in an enormous mooshroom island, surrounded by every biome in the game, probably doesn’t sound scary. Every crumbling piece of architecture, every wandering zombie, is just another spine-tingling reminder of the impermanence of life. There’s something deeply and existentially horrifying about this seed. Everywhere you look, the villages are abandoned or infested, and their ancient structures lie untouched for you to explore - if you have the guts to brave them, that is. Monsters abound, but you seem to be the only living soul for miles in any direction. The village, however, is entirely devoid of life, implying that the cold overtook the residents long ago, but “devoid of life” doesn’t mean “unoccupied.” 9. This seed spawns you near a village on the edge of a snowy tundra biome. This is why stories like Into Thin Air and the simple mechanic of powdered snow in Minecraft trigger our fight or flight reflexes - we know that the cold is a slow and painful way to go out. Hypothermia is definitely one of the most viscerally terrifying ways to die. If media intended to startle or sink dread into your bones is endlessly fascinating and exciting to you, here are ten Minecraft seeds that are sure to get you your thrill fix! Horror movies, scary games, true crime, Youtube channels about haunted doll collections… maybe that last one is a little too specific, but you get what I mean. If you’re anything like me - which if you’re reading this article, you almost definitely are - then you just can’t get enough of spooky things. Minecraft Scary Seeds That Are Fun! (2022 Edition) Will the benefit to patients justify the price of your product? Will insurers agree to cover it? If not, it may mean going back to the drawing board to rework the formulation or the manufacturing process. Or perhaps your new gene therapy turns out to be the next Zolgensma, with a price tag of over $2M per patient. Imagine having spent several years and several million investor dollars to get a drug candidate successfully through phase 1 clinical trials, only to learn that your manufacturing process is not suitable for commercial scale production or that the COGS is too high. Another is to make sure there is a sound product development plan (PDP) in place from the start. It is a multidisciplinary effort that requires extensive planning and coordination, as well as a clear vision of the end goal.Īs we saw previously, partnering with more experienced industry players who have been there before and know what to expect is one way that smaller biotech companies can improve their chances of success. For the best chance of success, it is imperative to start out with a realistic understanding of what lies ahead, and a solid plan of how to arrive at an end product that is not only marketable but will give a healthy return on investment.Įven with sound science and technology as the starting point, turning a lead candidate into a commercially viable drug is no easy feat. The PDP: Where Opportunity Meets Realityīringing a beneficial new drug or therapy to patients is an exciting opportunity and a worthy goal, but not without significant risks. For each stage of the development process, the PDP clarifies the major goals and critical success factors, specifying how success will be measured and what needs to be done to mitigate any risks.Ī well-designed PDP not only increases the chances of success, it also plays an important role in helping the program teams reduce cost of goods, maximize efficiency and shorten time to market. It serves as a step-by-step guide to arrive at the envisioned drug product. The PDP is a strategic document that creates a detailed and comprehensive picture of the development strategy. What is a Product Development Plan (PDP)? In this article, we explore why and how to use this pivotal tool to formulate a winning drug development strategy. How do investors and executive managers bridge the gap between identifying a promising drug candidate and turning out a commercially successful product? While there is no simple answer to this question, one thing is certain: behind every successful new drug, there is a well-crafted product development plan (PDP). Yet for every success, there are countless tales of defeat. In 2020, 63% of approved new therapeutic drugs in Europe and the US came from small-to-medium enterprises. Without doubt, biotech startups and smaller pharmaceutical companies have become the major drivers of innovation in the pharmaceutical industry. Fortunately, I discovered plenty of third-party duplicate file finder apps that make detecting and deleting duplicate files a breeze.įrom the many duplicate detection apps available on the web, I narrowed down 6 apps that performed well on my selection criteria. I couldn’t manually find and delete all these duplicate images (there were just too many). However, after investigating further, I discovered numerous duplicate photos and screenshots taking up an ungodly amount of storage space. At first, I attributed it to my Mac’s low base storage capacity-256 GB. Mere months after buying a sparkling new MacBook Air (M2), I found it running out of storage space. What is the best way to remove duplicate photos on Mac?Īre there any free duplicate photo finders for Mac? Are there Any Alternative Ways to Remove Duplicate Photos on Mac. 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Users can download the FolderPainter app from the official website.Īfter downloading the FolderPainter app, users can extract it into a folder using WinRAR. It is compatible with Windows 11, 10, 8.1, 8, and 7. Moreover, assigning different colors to folders makes them stand out, making them easy to identify.įolderPainter features an easy-to-use interface, and it is a portable program, so users do not have to install it to use it. By doing so, users can quickly access their favorite folders without searching through multiple folders. With this application, users can assign colors to their frequently accessed folders, such as setting red for urgent folders and green for standard folders, among others. Folder PainterįolderPainter is a freeware tool that facilitates changing the default yellow color of Windows folders to any other color. This action will launch the CustomFolders program, where users can modify the folder’s icon and color, as well as add an emblem to it. To customize a folder’s icon and color, simply right-click on it and select the CustomFolders option. Upon installation, the program integrates itself into the right-click context menu. StyleFolder Change Folder colors in Windows 10/11 CustomFoldersĬustomFolders is a portable and free software that enables users to customize the color and icon of folders on Windows 11/10 operating systems.Here is the list of the best seven freeware tools to change the folder icon color on Windows 11/10:. There are numerous free and paid software options available online, but we have chosen seven of the best free tools for changing folder icon colors on the Windows 10 operating system. If you require distinct colors for various folders to aid in identifying them, you can employ a free tool. As a result, if you wish to change the color of your folder icons, you will need to employ a third-party tool. Windows 11/10 enables you to customize individual folder icons for easier identification, but unfortunately, it does not provide an option to change the color of folder icons. The diamond will be lit using the indirect light of Global Illumination and Final Gather. Before entering into the caustics, the overall lighting of the scene can be improved. Also, since raytracing is in effect, the shadow is replaced with a raytraced shadow. Light needs to enter and exit the diamond, so refractions happen twice. It's black! This is because in the Render Global Settings, Raytracing is turned on, but Refractions are set to 1. An initial render produces the following result. As the diamond is sitting in air, the Col_out and Ior_out are left at their default value for air. The IoR is simply looked up in an IoR index. It can be adjusted latter if we want add a little color to the diamond. The Phong Coefficient will take care of how sharp or blurry the light rays will appear on a surface: higher values produce sharp highlights and lower values glossy, or more blurry highlights.Ĭol is left at the default Value of 0.98. It is used to generate fake highlights of an area light source. To use the dielectric material the model normals must be oriented correctly unless the ignore_normals parameter is set to true. For a dielectric-dielectric interface the normals point into a dielectric material which is outside. For a dielectric-air interface the normals point into the air. The dielectric material will use the normals of the surface to distinguish the medium on either side of the interface. Whether a ray of light is entering or exiting an object can be determined by the direction of the object's normals. If your object is well model, Ignore_normals can be left off. If the glass object were immersed in water, the Ior_out would be changed to 1.33. For example, a glass object would have an Ior of 1.5 and an Ior_out of 1.0 because air is on the outside of the glass. When two dielectric materials are adjacent to each other then the Col_out and Ior_out are used to specify the respective values of the outside dielectric material. The Col and Ior attributes control how the light is behaving at either end of the object. Water has an IoR of 1.333 (4/3), Glass an IoR of 1.5 to 1.7, and Diamond an IoR of 2.419. IoR affectively controls the density of the medium. As light enters a medium denser than air, it bends. Ior is Index of Refraction of the dielectric material. This is where Beers law is used and affects how much light can pass through the medium. Thus 0.9 means that 10% of the light is absorbed per unit length of the material." (Maya Help manual). Col is more than just the color of the material, it also controls ".the fraction of light which is left after traversing one unit of material. There are six attributes to control the dielectric material: Col, Ior, Col_out, Ior_out, Ignore_normals and Phong_coef. So light that has entered our diamond will be less bright as it exists. Beers law states that light is absorbed exponentially as it travels through a material. Fresnel reflection controls the amount of specularity of a surface according to the camera angle: the more perpendicular the surface is to the camera the more reflective the surface becomes. Unlike a material with a high transparency setting, it also uses Fresnel reflection and Beers law of light absorption. The word dielectric refers to any material that is a poor conductor of electricity. I started by applying a dielectric material to the diamond.Ī dielectric material accurately simulates transparent objects such as glass, water and diamond. The results are convincing - it looks like a diamond - but can be improved. The diamond uses a Phong material for hard specular highlights and is set to be mostly transparent. It is lit by a high backlight casting a Depth Map Shadow onto the floor. To better appreciate the Caustics effect, the diamond is first set-up and rendered using a standard light and transparent material using Mental Ray. The diamond was modeled separately from a gem cutter diagram and then imported into a scene resembling a photographic studio - the virtual set. And just to add that touch of realism which indirect illumination creates, Global Illumination and Final Gather also need to be used. Also, to more accurately re-create the physical behavior of light in the diamond requires the use of a dielectric material. To achieve all this requires the use of Caustics to handle this refraction of light as it passes through a diamond and onto its supporting surface. Light doesn't just bounce off an object it enters it, bends, changes color, bounces back and looses intensity. Rendering a diamond as photo-realistically as possible is a 3D challenge. How to Patch Plaster Walls if the Lath is in Good Condition The patch is now ready to prime and paint. On the third day, spread another coat, and after it dries, smooth it gently with a damp sponge. Gently scrape it smooth and apply a second coat. Using a 6-inch taping knife, scrape the patch area smooth, and cover the patch with a thin layer of ready-mix joint compound. How to Repair Lath and Plaster in 6 Steps 1. It’s a common practice to replace missing plaster with a piece of blue board (a wall board made to be coated with plaster), but troweling on base coat is faster. Finish coats came after the base had dried. Several coats were applied, the first keying into the spaces between the lath to make a stable base. Into the 20 th century, plaster was applied over wood lath spaced half an inch or so apart over the studs or ceiling joists. If the lath is in good condition and you need to repair holes, patching is a matter of troweling on layers of mud. Don’t use so-called patching plaster sold at home centers, it’s much harder than the wall’s original plaster, and it sets in the blink of an eye. It’s better to use a softer, slower-setting lime-based plaster, like the one developed for Big Wally’s line of plaster-repair products, takes about an hour to set, isn’t prone to cracking or delaminating, and needs no sanding, which keeps dust to a minimum. How Do You Repair a Hole in Lath and Plaster Walls?įor lath and plaster repair, it’s important to use good techniques and the right materials. First, you’ll repair the lath and then patch the hole. If you’re dealing with damaged lath and plaster walls-for example gaping holes in the wall because of electrical work-here are techniques you can use to repair them. Chalice as a brand new playable character with a modified moveset and new abilities. Publisher: Studio MDHR Entertainment Inc. With the opportunity now available to download Cuphead for free for PC, theres no reason not to immerse yourself in this uniquely satisfying experience. Chalice’s unique abilities, players will take on a new cast of fearsome, larger than life bosses to assist the jolly Chef Saltbaker in Cuphead’s final challenging quest!ĭeveloper: Studio MDHR Entertainment Inc. Chalice for a rollicking adventure on a previously undiscovered Inkwell Isle! With the aid of new weapons, magical charms, and Ms. Each song is played by live musicians, including a 13-piece big band, 10-piece ragtime ensemble, a solo pianist, a vocalist, a tap dancer, and a few surprises. How To Download CUPHEAD PC For Free (1. Overview Cuphead: Cup head is a run and gun action video game which focuses heavily on boss battles. Brothers Cuphead and Mugman are joined by the clever, adventurous Ms. About Cuphead Official Soundtrack free steam key Composed by Kristofer Maddigan, the Cuphead OST features nearly 3 hours of original jazz, early big band, and ragtime music. Buy Cuphead and shop other great Nintendo products online at the official My Nintendo Store. Cuphead Free Download IGGGAMES On Steam Cuphead Free Download PC Free With DLCs Android APK For Mac OS Direct Download. Inspired by cartoons of the 1930s, the visuals and audio are painstakingly created with the same techniques of the era, i.e. If your Mac is even older than that, it will really depend on your machine’s graphics. Download Cuphead The Delicious Last Course for Mac OS:Ĭuphead The Delicious Last Course is anew DLC. Cuphead is a classic run and gun action game heavily focused on boss battles. Our test 2013 Macbook Pro ran the game at 56.7 FPS, which is way above our target. Your VPC network must be configured toĪllow access to. This section describes how to create a Windows Server instance that has anĮxternal IP address. Create a Windows Server instance that uses an external IP to activate The Security Database on the Server does not have a Computer Account for this Workstation Trust Relationship. As a result, you might encounter the following error Make sure the instance name is no longer than 15 characters, to meet the statedĪD uses the NetBIOS names of machines, which are generated as the instance name If you plan on using Microsoft Active Directory (AD) with your new instance, Review configuring access to toĮnsure your VPC network allows access to the activation serverīefore you create your first Windows instance. Note: All Windows Server instances must be able to communicate with Information, see License your RDS deployment with client access licenses Purchase Remote Desktop Session (RDS) Client Access Licenses (CALs). If you need more than two concurrent remote desktop sessions, you will need to Shielded VM images offer security features like UEFI-compliantįirmware, Secure Boot, and vTPM-protected Measured Boot. To create an instance with Windows Server, specify the imageįamily for the specific version of Windows that you need.Ĭompute Engine offers several versions of Windows Server, most of You use the credentials you provide to the gcloud CLI. To use the REST API samples on this page in a local development environment, To use the Python samples on this page from a local To use the Node.js samples on this page from a local To use the Java samples on this page from a local Set up authentication for a local development environment. To initialize the gcloud CLI, run the following command:Ĭreate local authentication credentials for your Google Account: Then set up Application Default Credentials with your user credentials. To use the Go samples on this page from a localĭevelopment environment, install and initialize the gcloud CLI, and Previously, make sure you have the latest version by running gcloud components Gcloud init Note: If you installed the gcloud CLI Initialize it by running the following command: In the image above, the edited nf file is successfully uploaded to the server via FTP after changing the file’s permissions from 644 to 777.When you use the Google Cloud console to access Google Cloud services andĪPIs, you don't need to set up authentication. Now that the file has permissions of 777, you will be able to upload it to your server successfully via FTP. Go back to your FTP Client and try uploading the saved file again. Sudo /opt/bitnami/ctlscript.sh restart apache In the image above, the command sudo service apache2 graceful is executed to restart the server in order for file permission changes to take effect.įor most Apache configurations, run the following restart command:įor Bitnami Apache configurations, run the following restart command: In the image above, the command sudo chmod 777 /etc/apache2/sites-available/nf is executed in order to change the permissions of the “nf” file from 644 to 777.įor changes to take affect, you will need to restart your Apache server. To fix this problem, you are going to change the file’s permissions from 644 to 777. As you can see from the image, the file’s permissions are set to 644.īecause the file’s permissions are set to 644, you would not have sufficient permissions to edit the file via FTP. In the image above, the command stat -c "%a %n" /etc/apache2/sites-available/nf is used to check the permissions of the nf file. To do this, execute the following command: In this example, the user would be checking the permissions of the nf file. Now that you’ve connected to your website via SSH, the first step is to check the permissions of the file you want to edit. Go to your Compute Engine, then to VM instances to access your VM instance.Ĭlick on the SSH button to connect to your website via SSH. This requires you to connect to your VM instance using the SSH (Linux Shell) terminal. In order to fix the problem, you will need to edit the file’s permissions in Google Cloud Platform. In the image above, the user is attempting to save changes to their website’s nf file via FTP.īecause the user does not have the required permissions to save changes to the nf file, the FTP console is showing Permission denied – File transfer failed. Permission denied errors occur when you don’t have the required permissions to make changes to a file that you’re trying to edit over FTP. What is a Permission denied error in FTP, and what does it look like? Are you getting Permission denied errors when trying to edit your Google Cloud Platform files via FTP?įollow below 6 steps to fix the permission issue: Our Basic and Translational Cardiovascular Research Training Program (CVTP) provides broad interdisciplinary training in studies of basic cardiovascular biology and disease as well other diseases such as cancer, diabetes, and neurodegenerative diseases where cardiovascular dysfunction plays a critical role. Trainees get exposure to nearly all major scientific disciplines including cell and molecular biology, immunology, biomedical engineering and medical imaging, biophysics, structural biology, bioinformatics, data sciences, systems analyses, neuroscience, biochemistry, pharmacology, and genetics/omics. In addition, there is now compelling evidence that many of the exciting new anti-cancer drugs while highly effective in treating cancer, they greatly exacerbate CVD progression such that many cancer survivors are more likely to die of CVD rather than to reoccurrence of their cancer. As such there is an urgent need for training biomedical scientists to study CVD mechanisms and to develop more effective therapies to treat or prevent it, as well as alternative drugs for treating other non-CVD diseases that do not have the unfortunate side effect of exacerbating CVD development. Indeed, CVD and CVD-related deaths are expected to markedly increase in prevalence in the next decade due to global Westernization and the associated obesity epidemic which accelerates the progression of CVD resulting in much earlier onset of late-stage clinical events including heart attacks, stroke, and heart failure. However, unfortunately this has only modestly reduced CVD and CVD-related deaths. Research advances, including many developed here at UVA, have led to the identification of powerful new therapies for reducing cholesterol levels and for treating high blood pressure or hypertension. Thus, highly innovative and high impact CVD research is not only timely, it’s imperative for human health. Taken together, CVD and CVD-related diseases account for >80% of all deaths globally. CVD or cardiovascular dysfunction also contributes to marked exacerbation of a number of major non-CVD diseases including cancer, renal failure, neurodegenerative disease, and the clinical complications of diabetes. Intellectual Property (IP) and Entrepreneurial ActivitiesĬardiovascular disease (CVD) is the leading cause of death in the USA and worldwide with ischemic heart disease, stroke, and heart failure being responsible for >30% of all deaths.
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